RapamycinFungusV1, Main, Exploration, bibRecord, 000747

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

Identifieur interne : 000747 ( Main/Exploration ); précédent : 000746; suivant : 000748

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

Auteurs : Julien Moretti [États-Unis] ; Soumit Roy [États-Unis] ; Dominique Bozec [États-Unis] ; Jennifer Martinez [États-Unis] ; Jessica R. Chapman [États-Unis] ; Beatrix Ueberheide [États-Unis] ; Dudley W. Lamming [États-Unis] ; Zhijian J. Chen [États-Unis] ; Tiffany Horng [États-Unis] ; Garabet Yeretssian [États-Unis] ; Douglas R. Green [États-Unis] ; J Magarian Blander [États-Unis]

Source :

Cell [ 1097-4172 ] ; 2017.

RBID : pubmed:29056340

Descripteurs français

KwdFr :
- Animaux (MeSH), Autophagie (MeSH), Bactéries à Gram positif (physiologie), Femelle (MeSH), Infections bactériennes à Gram positif (immunologie), Molécules contenant des motifs associés aux pathogènes (métabolisme), Mâle (MeSH), Phagocytes (immunologie), Protéines membranaires (métabolisme), Réticulum endoplasmique (métabolisme), Souris (MeSH), Stress du réticulum endoplasmique (MeSH), Sérine-thréonine kinases TOR (métabolisme).
MESH :
- immunologie : Infections bactériennes à Gram positif, Phagocytes.
- métabolisme : Molécules contenant des motifs associés aux pathogènes, Protéines membranaires, Réticulum endoplasmique, Sérine-thréonine kinases TOR.
- physiologie : Bactéries à Gram positif.
- Animaux, Autophagie, Femelle, Mâle, Souris, Stress du réticulum endoplasmique.

English descriptors

KwdEn :
- Animals (MeSH), Autophagy (MeSH), Endoplasmic Reticulum (metabolism), Endoplasmic Reticulum Stress (MeSH), Female (MeSH), Gram-Positive Bacteria (physiology), Gram-Positive Bacterial Infections (immunology), Male (MeSH), Membrane Proteins (metabolism), Mice (MeSH), Pathogen-Associated Molecular Pattern Molecules (metabolism), Phagocytes (immunology), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , metabolism : Membrane Proteins, Pathogen-Associated Molecular Pattern Molecules, TOR Serine-Threonine Kinases.
- immunology : Gram-Positive Bacterial Infections, Phagocytes.
- metabolism : Endoplasmic Reticulum.
- physiology : Gram-Positive Bacteria.
- Animals, Autophagy, Endoplasmic Reticulum Stress, Female, Male, Mice.

Abstract

Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity and comprises primordial innate defense. Phagocytes mobilize interferon-inducible responses upon engagement of well-characterized signaling pathways by pathogen-associated molecular patterns (PAMPs). The signals controlling deployment of constitutive cell-autonomous responses during infection have remained elusive. Vita-PAMPs denote microbial viability, signaling the danger of cellular exploitation by intracellular pathogens. We show that cyclic-di-adenosine monophosphate in live Gram-positive bacteria is a vita-PAMP, engaging the innate sensor stimulator of interferon genes (STING) to mediate endoplasmic reticulum (ER) stress. Subsequent inactivation of the mechanistic target of rapamycin mobilizes autophagy, which sequesters stressed ER membranes, resolves ER stress, and curtails phagocyte death. This vita-PAMP-induced ER-phagy additionally orchestrates an interferon response by localizing ER-resident STING to autophagosomes. Our findings identify stress-mediated ER-phagy as a cell-autonomous response mobilized by STING-dependent sensing of a specific vita-PAMP and elucidate how innate receptors engage multilayered homeostatic mechanisms to promote immunity and survival after infection.

DOI: 10.1016/j.cell.2017.09.034
PubMed: 29056340
PubMed Central: PMC5811766

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000698
to stream Main, to step Curation: 000698

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.</title>
<author><name sortKey="Moretti, Julien" sort="Moretti, Julien" uniqKey="Moretti J" first="Julien" last="Moretti">Julien Moretti</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Ithaca (New York)</settlement>
</placeName>
<orgName type="university">Université Cornell</orgName>
</affiliation>
</author>
<author><name sortKey="Roy, Soumit" sort="Roy, Soumit" uniqKey="Roy S" first="Soumit" last="Roy">Soumit Roy</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bozec, Dominique" sort="Bozec, Dominique" uniqKey="Bozec D" first="Dominique" last="Bozec">Dominique Bozec</name>
<affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinez, Jennifer" sort="Martinez, Jennifer" uniqKey="Martinez J" first="Jennifer" last="Martinez">Jennifer Martinez</name>
<affiliation wicri:level="2"><nlm:affiliation>Immunity, Inflammation, and Disease Laboratory, Inflammation and Autoimmunity Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Immunity, Inflammation, and Disease Laboratory, Inflammation and Autoimmunity Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chapman, Jessica R" sort="Chapman, Jessica R" uniqKey="Chapman J" first="Jessica R" last="Chapman">Jessica R. Chapman</name>
<affiliation wicri:level="2"><nlm:affiliation>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ueberheide, Beatrix" sort="Ueberheide, Beatrix" uniqKey="Ueberheide B" first="Beatrix" last="Ueberheide">Beatrix Ueberheide</name>
<affiliation wicri:level="2"><nlm:affiliation>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lamming, Dudley W" sort="Lamming, Dudley W" uniqKey="Lamming D" first="Dudley W" last="Lamming">Dudley W. Lamming</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Zhijian J" sort="Chen, Zhijian J" uniqKey="Chen Z" first="Zhijian J" last="Chen">Zhijian J. Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Horng, Tiffany" sort="Horng, Tiffany" uniqKey="Horng T" first="Tiffany" last="Horng">Tiffany Horng</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yeretssian, Garabet" sort="Yeretssian, Garabet" uniqKey="Yeretssian G" first="Garabet" last="Yeretssian">Garabet Yeretssian</name>
<affiliation wicri:level="2"><nlm:affiliation>The Leona M. and Harry B. Helmsley Charitable Trust, New York, NY 10169, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Leona M. and Harry B. Helmsley Charitable Trust, New York, NY 10169</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Green, Douglas R" sort="Green, Douglas R" uniqKey="Green D" first="Douglas R" last="Green">Douglas R. Green</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blander, J Magarian" sort="Blander, J Magarian" uniqKey="Blander J" first="J Magarian" last="Blander">J Magarian Blander</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. Electronic address: jmblander@med.cornell.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10021</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Ithaca (New York)</settlement>
</placeName>
<orgName type="university">Université Cornell</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:29056340</idno>
<idno type="pmid">29056340</idno>
<idno type="doi">10.1016/j.cell.2017.09.034</idno>
<idno type="pmc">PMC5811766</idno>
<idno type="wicri:Area/Main/Corpus">000698</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000698</idno>
<idno type="wicri:Area/Main/Curation">000698</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000698</idno>
<idno type="wicri:Area/Main/Exploration">000698</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.</title>
<author><name sortKey="Moretti, Julien" sort="Moretti, Julien" uniqKey="Moretti J" first="Julien" last="Moretti">Julien Moretti</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Ithaca (New York)</settlement>
</placeName>
<orgName type="university">Université Cornell</orgName>
</affiliation>
</author>
<author><name sortKey="Roy, Soumit" sort="Roy, Soumit" uniqKey="Roy S" first="Soumit" last="Roy">Soumit Roy</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bozec, Dominique" sort="Bozec, Dominique" uniqKey="Bozec D" first="Dominique" last="Bozec">Dominique Bozec</name>
<affiliation wicri:level="2"><nlm:affiliation>Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinez, Jennifer" sort="Martinez, Jennifer" uniqKey="Martinez J" first="Jennifer" last="Martinez">Jennifer Martinez</name>
<affiliation wicri:level="2"><nlm:affiliation>Immunity, Inflammation, and Disease Laboratory, Inflammation and Autoimmunity Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Immunity, Inflammation, and Disease Laboratory, Inflammation and Autoimmunity Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chapman, Jessica R" sort="Chapman, Jessica R" uniqKey="Chapman J" first="Jessica R" last="Chapman">Jessica R. Chapman</name>
<affiliation wicri:level="2"><nlm:affiliation>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ueberheide, Beatrix" sort="Ueberheide, Beatrix" uniqKey="Ueberheide B" first="Beatrix" last="Ueberheide">Beatrix Ueberheide</name>
<affiliation wicri:level="2"><nlm:affiliation>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lamming, Dudley W" sort="Lamming, Dudley W" uniqKey="Lamming D" first="Dudley W" last="Lamming">Dudley W. Lamming</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Zhijian J" sort="Chen, Zhijian J" uniqKey="Chen Z" first="Zhijian J" last="Chen">Zhijian J. Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Horng, Tiffany" sort="Horng, Tiffany" uniqKey="Horng T" first="Tiffany" last="Horng">Tiffany Horng</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yeretssian, Garabet" sort="Yeretssian, Garabet" uniqKey="Yeretssian G" first="Garabet" last="Yeretssian">Garabet Yeretssian</name>
<affiliation wicri:level="2"><nlm:affiliation>The Leona M. and Harry B. Helmsley Charitable Trust, New York, NY 10169, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Leona M. and Harry B. Helmsley Charitable Trust, New York, NY 10169</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Green, Douglas R" sort="Green, Douglas R" uniqKey="Green D" first="Douglas R" last="Green">Douglas R. Green</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blander, J Magarian" sort="Blander, J Magarian" uniqKey="Blander J" first="J Magarian" last="Blander">J Magarian Blander</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. Electronic address: jmblander@med.cornell.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10021</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Ithaca (New York)</settlement>
</placeName>
<orgName type="university">Université Cornell</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell</title>
<idno type="eISSN">1097-4172</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Autophagy (MeSH)</term>
<term>Endoplasmic Reticulum (metabolism)</term>
<term>Endoplasmic Reticulum Stress (MeSH)</term>
<term>Female (MeSH)</term>
<term>Gram-Positive Bacteria (physiology)</term>
<term>Gram-Positive Bacterial Infections (immunology)</term>
<term>Male (MeSH)</term>
<term>Membrane Proteins (metabolism)</term>
<term>Mice (MeSH)</term>
<term>Pathogen-Associated Molecular Pattern Molecules (metabolism)</term>
<term>Phagocytes (immunology)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Autophagie (MeSH)</term>
<term>Bactéries à Gram positif (physiologie)</term>
<term>Femelle (MeSH)</term>
<term>Infections bactériennes à Gram positif (immunologie)</term>
<term>Molécules contenant des motifs associés aux pathogènes (métabolisme)</term>
<term>Mâle (MeSH)</term>
<term>Phagocytes (immunologie)</term>
<term>Protéines membranaires (métabolisme)</term>
<term>Réticulum endoplasmique (métabolisme)</term>
<term>Souris (MeSH)</term>
<term>Stress du réticulum endoplasmique (MeSH)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Proteins</term>
<term>Pathogen-Associated Molecular Pattern Molecules</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections bactériennes à Gram positif</term>
<term>Phagocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Gram-Positive Bacterial Infections</term>
<term>Phagocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endoplasmic Reticulum</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Molécules contenant des motifs associés aux pathogènes</term>
<term>Protéines membranaires</term>
<term>Réticulum endoplasmique</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Bactéries à Gram positif</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gram-Positive Bacteria</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Autophagy</term>
<term>Endoplasmic Reticulum Stress</term>
<term>Female</term>
<term>Male</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Autophagie</term>
<term>Femelle</term>
<term>Mâle</term>
<term>Souris</term>
<term>Stress du réticulum endoplasmique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity and comprises primordial innate defense. Phagocytes mobilize interferon-inducible responses upon engagement of well-characterized signaling pathways by pathogen-associated molecular patterns (PAMPs). The signals controlling deployment of constitutive cell-autonomous responses during infection have remained elusive. Vita-PAMPs denote microbial viability, signaling the danger of cellular exploitation by intracellular pathogens. We show that cyclic-di-adenosine monophosphate in live Gram-positive bacteria is a vita-PAMP, engaging the innate sensor stimulator of interferon genes (STING) to mediate endoplasmic reticulum (ER) stress. Subsequent inactivation of the mechanistic target of rapamycin mobilizes autophagy, which sequesters stressed ER membranes, resolves ER stress, and curtails phagocyte death. This vita-PAMP-induced ER-phagy additionally orchestrates an interferon response by localizing ER-resident STING to autophagosomes. Our findings identify stress-mediated ER-phagy as a cell-autonomous response mobilized by STING-dependent sensing of a specific vita-PAMP and elucidate how innate receptors engage multilayered homeostatic mechanisms to promote immunity and survival after infection.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29056340</PMID>
<DateCompleted><Year>2017</Year>
<Month>11</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-4172</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>171</Volume>
<Issue>4</Issue>
<PubDate><Year>2017</Year>
<Month>Nov</Month>
<Day>02</Day>
</PubDate>
</JournalIssue>
<Title>Cell</Title>
<ISOAbbreviation>Cell</ISOAbbreviation>
</Journal>
<ArticleTitle>STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.</ArticleTitle>
<Pagination><MedlinePgn>809-823.e13</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0092-8674(17)31128-5</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cell.2017.09.034</ELocationID>
<Abstract><AbstractText>Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity and comprises primordial innate defense. Phagocytes mobilize interferon-inducible responses upon engagement of well-characterized signaling pathways by pathogen-associated molecular patterns (PAMPs). The signals controlling deployment of constitutive cell-autonomous responses during infection have remained elusive. Vita-PAMPs denote microbial viability, signaling the danger of cellular exploitation by intracellular pathogens. We show that cyclic-di-adenosine monophosphate in live Gram-positive bacteria is a vita-PAMP, engaging the innate sensor stimulator of interferon genes (STING) to mediate endoplasmic reticulum (ER) stress. Subsequent inactivation of the mechanistic target of rapamycin mobilizes autophagy, which sequesters stressed ER membranes, resolves ER stress, and curtails phagocyte death. This vita-PAMP-induced ER-phagy additionally orchestrates an interferon response by localizing ER-resident STING to autophagosomes. Our findings identify stress-mediated ER-phagy as a cell-autonomous response mobilized by STING-dependent sensing of a specific vita-PAMP and elucidate how innate receptors engage multilayered homeostatic mechanisms to promote immunity and survival after infection.</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moretti</LastName>
<ForeName>Julien</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roy</LastName>
<ForeName>Soumit</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bozec</LastName>
<ForeName>Dominique</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martinez</LastName>
<ForeName>Jennifer</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Immunity, Inflammation, and Disease Laboratory, Inflammation and Autoimmunity Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chapman</LastName>
<ForeName>Jessica R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ueberheide</LastName>
<ForeName>Beatrix</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Office of Collaborative Science, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lamming</LastName>
<ForeName>Dudley W</ForeName>
<Initials>DW</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Zhijian J</ForeName>
<Initials>ZJ</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Horng</LastName>
<ForeName>Tiffany</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yeretssian</LastName>
<ForeName>Garabet</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>The Leona M. and Harry B. Helmsley Charitable Trust, New York, NY 10169, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Green</LastName>
<ForeName>Douglas R</ForeName>
<Initials>DR</Initials>
<AffiliationInfo><Affiliation>Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blander</LastName>
<ForeName>J Magarian</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. Electronic address: jmblander@med.cornell.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>S10 OD010582</GrantID>
<Acronym>OD</Acronym>
<Agency>NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 DK111862</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R00 AG041765</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI127658</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 DK072201</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI102964</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI073899</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI095245</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>K99 AG041765</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R21 AI080959</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI040646</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R56 AI073899</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI123284</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>10</Month>
<Day>19</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Cell</MedlineTA>
<NlmUniqueID>0413066</NlmUniqueID>
<ISSNLinking>0092-8674</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C530855">MPYS protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000069452">Pathogen-Associated Molecular Pattern Molecules</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="C546843">mTOR protein, mouse</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nat Cell Biol. 2018 Mar;20(3):224</RefSource>
<PMID Version="1">29476157</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Autophagy. 2018;14(6):1102-1104</RefSource>
<PMID Version="1">29782215</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004721" MajorTopicYN="N">Endoplasmic Reticulum</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059865" MajorTopicYN="N">Endoplasmic Reticulum Stress</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006094" MajorTopicYN="N">Gram-Positive Bacteria</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016908" MajorTopicYN="N">Gram-Positive Bacterial Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000069452" MajorTopicYN="N">Pathogen-Associated Molecular Pattern Molecules</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010586" MajorTopicYN="N">Phagocytes</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ER stress</Keyword>
<Keyword MajorTopicYN="N">ER-phagy</Keyword>
<Keyword MajorTopicYN="N">Gram-positive bacteria</Keyword>
<Keyword MajorTopicYN="N">STING</Keyword>
<Keyword MajorTopicYN="N">autophagy</Keyword>
<Keyword MajorTopicYN="N">c-di-AMP</Keyword>
<Keyword MajorTopicYN="N">cell-autonomous innate immunity</Keyword>
<Keyword MajorTopicYN="N">mTOR</Keyword>
<Keyword MajorTopicYN="N">type-I interferon</Keyword>
<Keyword MajorTopicYN="N">vita-PAMP</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>02</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>05</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>09</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>10</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>11</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>10</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29056340</ArticleId>
<ArticleId IdType="pii">S0092-8674(17)31128-5</ArticleId>
<ArticleId IdType="doi">10.1016/j.cell.2017.09.034</ArticleId>
<ArticleId IdType="pmc">PMC5811766</ArticleId>
<ArticleId IdType="mid">NIHMS930269</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>FEMS Immunol Med Microbiol. 2003 Apr 1;35(3):207-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12648839</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2016 Jun;23 (6):915-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26990661</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2016 Nov;18(11):1173-1184</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27749824</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Microbiol. 2013 Aug;11(8):513-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23812326</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Allergy Clin Immunol. 2016 Jul;138(1):28-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27373323</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2012 Dec 14;37(6):986-997</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23219390</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2012 Aug 17;150(4):803-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22901810</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Host Microbe. 2015 Jun 10;17(6):799-810</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26048138</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Host Microbe. 2009 Jul 23;6(1):10-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19616762</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Sci. 2014 Sep 15;127(Pt 18):4078-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25052096</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2012 Feb 24;12 (3):215-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22362354</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Today. 1992 Jan;13(1):11-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1739426</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2012 Nov 1;189(9):4630-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23028052</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2006 Sep;6(9):644-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16932750</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2015 Nov 2;11(11):1956-1977</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26389781</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2010 Dec 23;468(7327):1100-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21179166</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Leukoc Biol. 2017 Jan;101(1):77-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27733577</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2013 May 28;4(3):e00282-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23716572</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2009 Oct 8;461(7265):788-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19776740</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Rep. 2012 Dec 27;2(6):1475-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23219552</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Proteomics. 2014 Sep;13(9):2513-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24942700</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2011 May 22;474(7351):385-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21602824</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2010 Feb 26;32(2):279-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20171123</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2007 Feb;14 (2):230-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16794605</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2011 Mar;13(3):184-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21364565</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Host Microbe. 2015 Jun 10;17(6):788-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26028365</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 May 22;8(5):e64129</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23717549</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Elife. 2016 Feb 19;5:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26894960</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2010 Jun 25;328(5986):1703-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20508090</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2015 Jun 18;522(7556):354-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26040720</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Cell Biol. 2012 May;22(5):274-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22444729</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Host Microbe. 2015 Jun 10;17 (6):811-819</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26048136</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):89-102</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22251901</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Physiol. 2018 May;233(5):3867-3874</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28777470</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Immunol Med Microbiol. 2004 Jan 15;40(1):1-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14734180</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E747-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25583510</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2014 Mar 27;157(1):65-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24679527</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2013 May 10;340(6133):701-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23661752</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2012 Apr 25;12(5):367-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22531325</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19926846</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2013 Jan;14(1):19-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23238760</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16544-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24052526</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dev Cell. 2013 Apr 29;25(2):116-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23639440</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Microbiol. 2014 Feb;12(2):101-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24384599</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Endocrinol. 2017 Nov 5;455:13-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27884780</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2017 Mar 9;168(6):960-976</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28283069</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2013 Oct 24;155(3):688-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24119841</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2007 May-Jun;3(3):285-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17351330</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2015 Mar 15;194(6):2455-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25747907</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>Massachusetts</li>
<li>Tennessee</li>
<li>Texas</li>
<li>Wisconsin</li>
<li>État de New York</li>
</region>
<settlement><li>Ithaca (New York)</li>
</settlement>
<orgName><li>Université Cornell</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Moretti, Julien" sort="Moretti, Julien" uniqKey="Moretti J" first="Julien" last="Moretti">Julien Moretti</name>
</region>
<name sortKey="Blander, J Magarian" sort="Blander, J Magarian" uniqKey="Blander J" first="J Magarian" last="Blander">J Magarian Blander</name>
<name sortKey="Bozec, Dominique" sort="Bozec, Dominique" uniqKey="Bozec D" first="Dominique" last="Bozec">Dominique Bozec</name>
<name sortKey="Chapman, Jessica R" sort="Chapman, Jessica R" uniqKey="Chapman J" first="Jessica R" last="Chapman">Jessica R. Chapman</name>
<name sortKey="Chen, Zhijian J" sort="Chen, Zhijian J" uniqKey="Chen Z" first="Zhijian J" last="Chen">Zhijian J. Chen</name>
<name sortKey="Green, Douglas R" sort="Green, Douglas R" uniqKey="Green D" first="Douglas R" last="Green">Douglas R. Green</name>
<name sortKey="Horng, Tiffany" sort="Horng, Tiffany" uniqKey="Horng T" first="Tiffany" last="Horng">Tiffany Horng</name>
<name sortKey="Lamming, Dudley W" sort="Lamming, Dudley W" uniqKey="Lamming D" first="Dudley W" last="Lamming">Dudley W. Lamming</name>
<name sortKey="Martinez, Jennifer" sort="Martinez, Jennifer" uniqKey="Martinez J" first="Jennifer" last="Martinez">Jennifer Martinez</name>
<name sortKey="Roy, Soumit" sort="Roy, Soumit" uniqKey="Roy S" first="Soumit" last="Roy">Soumit Roy</name>
<name sortKey="Ueberheide, Beatrix" sort="Ueberheide, Beatrix" uniqKey="Ueberheide B" first="Beatrix" last="Ueberheide">Beatrix Ueberheide</name>
<name sortKey="Yeretssian, Garabet" sort="Yeretssian, Garabet" uniqKey="Yeretssian G" first="Garabet" last="Yeretssian">Garabet Yeretssian</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000747 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000747 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29056340
   |texte=   STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29056340" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki